General Transcription Factor IIB Overexpression and a Potential Link to Proliferation in Human Hepatocellular Carcinoma

@article{Li2012GeneralTF,
  title={General Transcription Factor IIB Overexpression and a Potential Link to Proliferation in Human Hepatocellular Carcinoma},
  author={Liren Li and Aixian Zhang and Xiaolei Cao and Jing Chen and Yunfei Xia and Hui Zhao and Ai-Guo Shen},
  journal={Pathology & Oncology Research},
  year={2012},
  volume={19},
  pages={195-203}
}
The general transcription factor IIB (TFIIB) plays a central role in preinitiation complex (PIC) assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II (RNA POLII). TFIIB functionally counteracts the transcriptional activation of hepatitis B virus X protein (HBx), which has been shown to play a role in the development of human… CONTINUE READING