General Nature of the Genetic Code for Proteins

@article{Crick1961GeneralNO,
  title={General Nature of the Genetic Code for Proteins},
  author={Francis H. C. Crick and Leslie Barnett and Sydney Brenner and R. J. Watts-tobin},
  journal={Nature},
  year={1961},
  volume={192},
  pages={1227-1232}
}
In this paper Crick, Brenner, and their collaborators described a very elegant series of genetic experiments by which they proved that the genetic code for protein was a triplet code. They used an acridine dye, proflavin, to induce mutations in a specific, well-studied gene of a virus, a so-called bacteriophage, that attacked the bacterium Escherichia coli. The effect of proflavin was to either eliminate a single nucleotide from the gene or to add a nucleotide, each of which had the effect… 
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