Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

@article{Mummidi1998GenealogyOT,
  title={Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression},
  author={Srinivas Mummidi and Seema S. Ahuja and Enrique Gonalez and Stephanie A. Anderson and Elvin N. Santiago and Kevin T. Stephan and Fiona E. Craig and Peter O’Connell and Victor Tryon and Robert A. Clark and Matthew J. Dolan and Sunil K Ahuja},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={786-793}
}
Allelic variants for the HIV-1 co-receptors chemokine receptor 5 (CCR5) and CCR2, as well as the ligand for the co-receptor CXCR4, stromal-derived factor (SDF-1), have been associated with a delay in disease progression. We began this study to test whether polymorphisms in the CCRS regulatory regions influence the course of HIV-1 disease, as well as to examine the role of the previously identified allelic variants in 1,090 HIV-1 infected individuals. Here we describe the evolutionary… 
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TLDR
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