GeneWise and Genomewise.

  title={GeneWise and Genomewise.},
  author={Ewan Birney and Michele Clamp and Richard Durbin},
  journal={Genome research},
  volume={14 5},
We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with… CONTINUE READING
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