GeneDecks: paralog hunting and gene-set distillation with GeneCards annotation.

@article{Stelzer2009GeneDecksPH,
  title={GeneDecks: paralog hunting and gene-set distillation with GeneCards annotation.},
  author={Gil Stelzer and Aron Inger and Tsviya Olender and Tsippi Iny-Stein and Irina Dalah and Arye Harel and Marilyn Safran and Doron Lancet},
  journal={Omics : a journal of integrative biology},
  year={2009},
  volume={13 6},
  pages={
          477-87
        }
}
Sophisticated genomic navigation strongly benefits from a capacity to establish a similarity metric among genes. GeneDecks is a novel analysis tool that provides such a metric by highlighting shared descriptors between pairs of genes, based on the rich annotation within the GeneCards compendium of human genes. The current implementation addresses information about pathways, protein domains, Gene Ontology (GO) terms, mouse phenotypes, mRNA expression patterns, disorders, drug relationships, and… 
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GIFtS can be a valuable tool for computational procedures which analyze lists of large set of genes resulting from wet-lab or computational research, and may also assist the scientific community with identification of groups of uncharacterized genes for diverse applications, such as delineation of novel functions and charting unexplored areas of the human genome.
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The evolution and architecture of this project is described, including examples of synergistic applications in diverse areas such as synthetic lethality in cancer, the annotation of genetic variations in disease, omics integration in a systems biology approach to kidney disease, and bioinformatics tools.
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