Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.

@article{Siprashvili2003GeneTV,
  title={Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.},
  author={Zurab Siprashvili and F. Anderst E. Scholl and Steven F. Oliver and Angie Adams and Christopher H. Contag and Paul A Wender and Paul A. Khavari},
  journal={Human gene therapy},
  year={2003},
  volume={14 13},
  pages={
          1225-33
        }
}
Nonviral gene transfer offers biosafety, stability, and expense advantages over viruses; however, it has suffered from poor efficiency. Because arginine-rich peptides facilitate uptake of macromolecules such as proteins, liposomes, and iron nanoparticles, we explored their potential in enhancing plasmid DNA delivery. In their unmodified form, known protein transduction sequences, including hepta-arginine and Tat(47-57), failed to support effective gene delivery. However, by flanking a core of… CONTINUE READING
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