Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?

@article{Maitland2010GeneTV,
  title={Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?},
  author={Norman J. Maitland and Karen S. Chambers and Lindsay J. Georgopoulos and Martha Simpson-Holley and Regina M. Leadley and Helen Evans and Magnus Essand and Angelika Danielsson and Wytske M van Weerden and Corrina M. A. de Ridder and Robert Kraaij and Chris H. Bangma},
  journal={Human gene therapy},
  year={2010},
  volume={21 7},
  pages={815-27}
}
Destruction of cancer cells by genetically modified viral and nonviral vectors has been the aim of many research programs. The ability to target cytotoxic gene therapies to the cells of interest is an essential prerequisite, and the treatment has always had the potential to provide better and more long-lasting therapy than existing chemotherapies. However, the potency of these infectious agents requires effective testing systems, in which hypotheses can be explored both in vitro and in vivo… CONTINUE READING