Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo

@article{Han2008GeneTU,
  title={Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo},
  author={Seung-lock Han and Yoon-Jong Lee and Haeng-Im Jung and Sung-Wook Lee and Sue-Jeong Lim and Seung-Hee Hong and Jin-sook Jeong},
  journal={Experimental & Molecular Medicine},
  year={2008},
  volume={40},
  pages={427-434}
}
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells, that limits adenoviral gene delivery, can be overcome by using adenovirus complexed with the liposome, Ad-PEGPE [1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly-ethylene glycol)-2000]. We first confirmed that CT-26 mouse colon cancer cells are deficient in CAR by RT-PCR, and… CONTINUE READING
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