Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector.

@article{Endo2007GeneTT,
  title={Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector.},
  author={Masayuki Endo and Philip W. Zoltick and Daniel C. Chung and Jean Bennett and Antoneta Radu and Nidal Muvarak and Alan W. Flake},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2007},
  volume={15 3},
  pages={579-87}
}
Ocular gene transfer has generally been approached by direct intraocular injection. In this study, we hypothesized that an opportunity exists during early gestation when specific ocular stem cell populations are accessible for gene transfer. These include the stem cell populations that maintain the cornea, lens, and retina throughout life. To test this hypothesis, we injected lentiviral vector encoding the green fluorescent protein (GFP) reporter gene into the murine amniotic space from the… CONTINUE READING
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