Gene transfer to human joints: progress toward a gene therapy of arthritis.

@article{Evans2005GeneTT,
  title={Gene transfer to human joints: progress toward a gene therapy of arthritis.},
  author={Christopher H. Evans and Paul D. Robbins and Steven C. Ghivizzani and Mary Chester Wasko and Matthew M Tomaino and Richard Kang and Thomas A Muzzonigro and Molly E Vogt and Elaine M. Elder and Theresa L Whiteside and Simon C. Watkins and James H. Herndon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 24},
  pages={8698-703}
}
This article describes the clinical application of gene therapy to a nonlethal disease, rheumatoid arthritis (RA). Intraarticular transfer of IL-1 receptor antagonist (IL-1Ra) cDNA reduces disease in animal models of RA. Whether this procedure is safe and feasible in humans was addressed in a phase I clinical study involving nine postmenopausal women with… CONTINUE READING