Gene transfer to cerebral blood vessels after subarachnoid hemorrhage.

  title={Gene transfer to cerebral blood vessels after subarachnoid hemorrhage.},
  author={Michael G Muhonen and Hiroaki Ooboshi and Michael J. Welsh and Beverly L. Davidson and Donald D. Heistad},
  volume={28 4},
  pages={822-8; discussion 828-9}
BACKGROUND AND PURPOSE Vasospasm remains a major cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. One step toward gene therapy to prevent spasm of cerebral vessels is to determine whether subarachnoid blood prevents transgene expression. METHODS Vasospasm was induced in mongrel dogs using the double-hemorrhage intracranial-injection model. Diameter of the basilar artery was assessed by angiography, and profound vasospasm (> 50% decrease in diameter) was demonstrated… CONTINUE READING


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