Gene transfer systems derived from Visna virus: analysis of virus production and infectivity.

  title={Gene transfer systems derived from Visna virus: analysis of virus production and infectivity.},
  author={Robert D. Berkowitz and Heini Ilves and Ivan Plavec and G{\'a}bor G{\'a}bor Veres},
  volume={279 1},
Efficient transfer of therapeutic genes into nondividing human cells can be accomplished by inserting the genes into lentiviruses and infecting the cells with the modified viruses. The most developed lentivirus gene transfer systems are based on HIV-1, but because of the widespread HIV epidemic, the use of HIV-based vectors for gene therapy may be associated with a safety risk. In an attempt to find another lentivirus which can transduce human cells and might be safer than HIV-1, we generated… CONTINUE READING


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