Gene transfer of truncated IkappaBalpha prevents tubulointerstitial injury.

  title={Gene transfer of truncated IkappaBalpha prevents tubulointerstitial injury.},
  author={Osamu Takase and Junichi Hirahashi and Atsushi Takayanagi and Akihiro Chikaraishi and Takeshi Marumo and Yuri Ozawa and Matsuhiko Hayashi and Nobuyoshi Shimizu and Takao Saruta},
  journal={Kidney international},
  volume={63 2},
BACKGROUND Severe proteinuria not only indicates the presence of progressive glomerular disease, but also causes tubular epithelial cells to produce inflammatory mediators leading to tubulointerstitial (TI) injury. We investigated the role of nuclear factor-kappaB (NF-kappaB) in tubular epithelial cells in the development of proteinuria-induced TI injury. METHODS To specifically inhibit NF-kappaB activation, a recombinant adenovirus vector expressing a truncated form of IkappaBalpha… CONTINUE READING
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