Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.

@article{Drynda2005GeneTO,
  title={Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.},
  author={Andreas Drynda and Paul H A Quax and Manfred Neumann and Willemijn H. van der Laan and G{\'e}za Pap and Susanne Drynda and Ingmar Meinecke and Joern Kekow and Wolfram H. Neumann and Tom W. J. Huizinga and Michael Naumann and W. K{\"o}nig and Thomas Pap},
  journal={Journal of immunology},
  year={2005},
  volume={174 10},
  pages={6524-31}
}
Apart from counteracting matrix metalloproteinases, tissue inhibitor of metalloproteinases-3 (TIMP-3) has proapoptotic properties. These features have been attributed to the inhibition of metalloproteinases involved in the shedding of cell surface receptors such as the TNFR. However, little is known about effects of TIMP-3 in cells that are not susceptible to apoptosis by TNF-alpha. In this study, we report that gene transfer of TIMP-3 into human rheumatoid arthritis synovial fibroblasts and… CONTINUE READING