Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins

@article{George1998GeneTO,
  title={Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins},
  author={SJ George and A M Baker and G Angelini and A C Newby},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={1552-1560}
}
Metalloproteinases (MMPs) are implicated in neointima formation and hence vein graft failure. Gene transfer to elevate local levels of tissue inhibitor of metalloproteinases (TIMPs) is therefore a potential treatment. In this study, we have used lumenal application of a replication-defective recombinant adenovirus to overexpress TIMP-2 and observe the effects on neointimal thickening in a well characterised human saphenous vein organ culture model. Increased TIMP-2 expression was localised to… CONTINUE READING
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A metalloproteinase inhibitor ( Ro 31 – 9790 ) inhibits smooth muscle cell proliferation and migration and neo - intima formation in human saphenous vein

  • S George, A Newby
  • Eur Heart J
  • 1996

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