Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway.

@article{Liu2006GeneTO,
  title={Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway.},
  author={Guei-Sheung Liu and L Liu and Che-Jen Lin and Jui-Cheng Tseng and Ming-Ju Chuang and Hing-Chung Lam and J Lee and L Yang and Julie Hwa Yu Chan and S. L. Howng and Ming-Hong Tai},
  journal={Molecular pharmacology},
  year={2006},
  volume={69 2},
  pages={440-51}
}
Pro-opiomelanocortin (POMC) is a prohormone of various neuropeptides, including corticotropin, alpha-melanocyte-stimulating hormone (alpha-MSH), and beta-endorphin (beta-EP). POMC neuropeptides are potent inflammation inhibitors and immunosuppressants and may exert opposite influences during tumorigenesis. However, the role of POMC expression in carcinogenesis remains elusive. We evaluated the antineoplastic potential of POMC gene delivery in a syngenic B16-F10 melanoma model. Adenovirus… CONTINUE READING