Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.

@article{Takeshita1996GeneTO,
  title={Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.},
  author={Satoshi Takeshita and Yukio Tsurumi and T Couffinahl and Takayuki Asahara and Christophe Bauters and James F Symes and Napoleone M. A. Ferrara and Jeffrey M. Isner},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1996},
  volume={75 4},
  pages={487-501}
}
Vascular endothelial growth factor (VEGF) is a naturally secreted endothelial cell-specific mitogen. We investigated the hypothesis that naked DNA encoding for VEGF could be used in a strategy of arterial gene therapy to stimulate collateral artery development. Plasmid DNA encoding each of the three principal human VEGF isoforms (phVEGF121, phVEGF165, or phVEGF189) was applied to the hydrogel polymer coating of an angioplasty balloon and delivered percutaneously to one iliac artery of rabbits… CONTINUE READING

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