Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes.

Abstract

Islet transplantation is a promising cure for diabetes. However, inflammation, allorejection, and recurrent autoimmune damage all may contribute to early graft loss. Pancreatic islets express lower levels of antioxidant genes than most other tissues of the body, and beta-cells in particular are sensitive to oxidative damage. Therefore, damage from oxidative… (More)

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