Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.

@article{Zheng2003GeneTO,
  title={Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.},
  author={Jie-sheng Zheng and Xiang-Qun Yang and Keith J. Lookingland and Gregory D. Fink and Christian Hesslinger and Gregory Kapatos and Imre Kovesdi and Alex F. Chen},
  journal={Circulation},
  year={2003},
  volume={108 10},
  pages={1238-45}
}
BACKGROUND We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Tetrahydrobiopterin (BH4), a potent reducing molecule with antioxidant properties and an essential cofactor for endothelial nitric oxide synthase, protects against O2--induced vascular dysfunction. However, the interaction between O2- and BH4 on endothelial function and the underlying mechanisms… CONTINUE READING