Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.

@article{Ono2004GeneTO,
  title={Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.},
  author={Masamichi Ono and Yoshiki Sawa and Norihide Fukushima and Hitoshi Suhara and Toshikazu Nakamura and Chieko Yokoyama and Tadashi Tanabe and Hikaru Matsuda},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={2004},
  volume={26 6},
  pages={1092-7}
}
OBJECTIVE Hepatocyte growth factor (HGF) is a multi-potent growth factor, which has anti-fibrotic effects for lung injuries. In this study, we investigated whether human HGF gene transfer may attenuate the medial hypertrophy of pulmonary arteries and enhance the ameliorating effect of prostacyclin in monocrotaline (MCT)-induced pulmonary hypertension in rats. METHODS AND RESULTS The day before MCT injection, HVJ-liposome complex with the cDNA encoding HGF gene (H group), PGIS gene (P group… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…