Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain.

@article{Chu2003GeneTO,
  title={Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain.},
  author={Yi Chu and Shinichiro Iida and D. Lund and Robert M. Weiss and Gerald F Dibona and Yoshimasa Watanabe and Frank M. Faraci and Donald D. Heistad},
  journal={Circulation research},
  year={2003},
  volume={92 4},
  pages={461-8}
}
Oxidative stress may contribute to hypertension. The goals of this study were to determine whether extracellular superoxide dismutase (ECSOD) reduces arterial pressure in spontaneously hypertensive rats (SHR) and whether its heparin-binding domain (HBD), which is responsible for cellular binding, is necessary for the function of ECSOD. Three days after intravenous injection of an adenoviral vector expressing human ECSOD (AdECSOD), mean arterial pressure (MAP) decreased from 165+/-4 mm Hg (mean… CONTINUE READING