Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures.

@article{Vittitow2002GeneTO,
  title={Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures.},
  author={Jason L. Vittitow and Rahul Garg and Laura-Leigh S Rowlette and David Lee Epstein and Edward T O'Brien and Terete Borr{\'a}s},
  journal={Molecular vision},
  year={2002},
  volume={8},
  pages={32-44}
}
PURPOSE To investigate the regulation of expression and the role of the RhoA gene in the human trabecular meshwork (TM). To attempt to modulate outflow facility by gene transfer of the RhoA gene's dominant-negative mutant protein. METHODS Total RNA extracted from cultured human trabecular meshwork (HTM) cells treated with outflow facility drugs were analyzed by northern blot hybridization using an amplified human RhoA cDNA from plasmid pZip-RhoA wild type (wt) [1]. A dominant-negative form of… CONTINUE READING
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Molecular Vision Molecular Vision

  • T Borras, BT Gabelt, GK Klintworth, JC Peterson, PL. Kaufman
  • J Gene
  • 2002
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