Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.

Abstract

We previously found that injection of a cocaine hydrolase (CocE) engineered from human butyrylcholinesterase will transiently accelerate cocaine metabolism in rats while reducing physiological and behavioral responses. To investigate more extended therapeutic effects, CocE cDNA was incorporated into a replication-incompetent type-5 adenoviral vector with a… (More)

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@article{Gao2005GeneTO, title={Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.}, author={Yang Gao and Elena A Atanasova and Nan Sui and James D. Pancook and Jeffry D. Watkins and Stephen Brimijoin}, journal={Molecular pharmacology}, year={2005}, volume={67 1}, pages={204-11} }