Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure.

Abstract

BACKGROUND Abnormalities of intracellular calcium handling are widely recognized as a common hallmark of heart failure in animal models and humans. Modifying the interaction of phospholamban (PLB) with the sarcoplasmic reticulum ATPase (SERCA) by PLB mutants improves cardiac function but may also lead to heart failure. In this study we describe the in vivo… (More)

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