Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents.

@article{Kido2005GeneTO,
  title={Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents.},
  author={Masakuni Kido and Lingling Du and Christopher Cyril Sullivan and Reena Deutsch and Stuart W. Jamieson and Patricia A. Thistlethwaite},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={129 2},
  pages={268-76}
}
OBJECTIVES Overexpression of angiopoietin 1 in the lung has been associated with human pulmonary hypertension. We hypothesized that inhibiting angiopoietin 1 signaling in the lung by administration of a receptor antagonist would block the development of pulmonary hypertensive vasculopathy in rodent models. METHODS We injected 2 and 4 x 10(10) genomic particles of adeno-associated virus containing an extracellular fragment of the TIE2 receptor (AAV-sTIE2) into the pulmonary artery of 60 rats… CONTINUE READING

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