Gene transfer of Fas ligand induces tumor regression in vivo.

  title={Gene transfer of Fas ligand induces tumor regression in vivo.},
  author={Hiroshi Arai and David Gordon and Elizabeth G. Nabel and Gary J. Nabel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 25},
The Fas-Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses. Herein, we report that gene transfer of FasL inhibits tumor cell growth in vivo. Although such inhibition is expected in Fas+ tumor cell lines, marked regression was unexpectedly observed after FasL gene transfer into the CT26 colon carcinoma that does not express Fas. Infection by an adenoviral vector encoding FasL rapidly eliminated… CONTINUE READING