Gene transfer into the mouse retina mediated by an adeno-associated viral vector.

@article{Ali1996GeneTI,
  title={Gene transfer into the mouse retina mediated by an adeno-associated viral vector.},
  author={Robin R Ali and Martin B. Reichel and Adrian J. Thrasher and Roland J. Levinsky and Christine Kinnon and Naheed Kanuga and David M Hunt and Shomi Shanker Bhattacharya},
  journal={Human molecular genetics},
  year={1996},
  volume={5 5},
  pages={591-4}
}
Gene transfer to photoreceptor cells may provide a means for arresting the retinal degeneration that is characteristic of many inherited causes of blindness, including retinitis pigmentosa (RP). However, transduction of photoreceptors has to date been inefficient, and further limited by toxicity and immune responses directed against vector-specific proteins. An alternative vector system based on adeno-associated virus (AAV) may obviate these problems, and may be useful for transduction of… CONTINUE READING