Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter.

  title={Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter.},
  author={Gregory D Chapman and Carol S Lim and R S Gammon and S C Culp and J S Desper and Robert P Bauman and J. L. Swain and Richard S Stack},
  journal={Circulation research},
  volume={71 1},
Genetic manipulation of the vasculature may offer insights into the pathogenesis of coronary artery disease and may lead to gene therapy for disorders such as restenosis after percutaneous coronary angioplasty. The goal of this study was to develop a percutaneous method for gene transfer into coronary arteries of intact animals. Liposomes were used to facilitate transfection in coronary arteries with a plasmid containing the cDNA encoding luciferase. This reporter was chosen since it is not… CONTINUE READING


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