Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses

@article{Flgel1999GeneTI,
  title={Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses},
  author={Alexander Fl{\"u}gel and Michael Willem and Tomasz Berkowicz and Hartmut Wekerle},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={843-847}
}
Encephalitogenic T cells can be isolated readily from naive or antigen-primed immune organs and propagated as clonal populations in vitro. These T-cell lines have helped us to understand better epitope recognition, TCR gene use, cytokine patterns, and T-cell interactions with components of the CNS (ref. 2), and have provided a basis for the design of new strategies to treat autoimmune diseases. However, essential steps in the development of autoimmune disease have remained obscure. For example… CONTINUE READING
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