Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

@article{Perales1994GeneTI,
  title={Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.},
  author={Jos{\'e} Carlos Perales and T Ferkol and H Beegen and Oscar D. Ratnoff and Richard W. Hanson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 9},
  pages={4086-90}
}
Receptor-mediated gene transfer has been used to introduce genes into tissues of animals in vivo. The genes introduced by this approach have been transiently expressed at low levels in animal tissues. High levels of expression, for longer periods, have been attained by the induction of cell division (i.e., partial hepatectomy) or disruption of lysosomal degradation of the DNA. We have studied the correlation of specific structural features on the DNA/ligand complexes with their ability to… CONTINUE READING
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