Gene transfer in regenerating muscle.

  title={Gene transfer in regenerating muscle.},
  author={Maurizio Vitadello and Maria Vittoria Schiaffino and Audrey Picard and Maurizio Scarpa and Stefano Schiaffino},
  journal={Human gene therapy},
  volume={5 1},
We have compared the efficiency of direct gene transfer in normal and regenerating rat skeletal muscle. Muscle necrosis and regeneration was induced by intramuscular injection of bupivacaine in the soleus muscle of adult rats. Plasmids containing beta-galactosidase (beta-gal) or chloramphenicol acetyltransferase (CAT) genes driven by viral promoters were injected 3 days after bupivacaine treatment into the regenerating and the contralateral uninjured muscles. Expression of CAT activity was > 80… CONTINUE READING
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