Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine.

@article{Dehshahri2009GeneTE,
  title={Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine.},
  author={Ali Dehshahri and R K Oskuee and Wayne Thomas Shier and Arash Hatefi and Mohammad Bagher Ramezani},
  journal={Biomaterials},
  year={2009},
  volume={30 25},
  pages={
          4187-94
        }
}
In this study, a series of alkyl-oligoamine derivatives of low-toxicity 10 kDa polyethylenimine (PEI) were synthesized to enhance the hydrophobicity of PEI while preserving most of its primary amine content. PEI was reacted with a series of omega-bromoalkylcarboxylic acids with different chain lengths (2-bromoacetic, 6-bromohexanoic, 10-bromodecanoic and 16-bromohexadecanoic acids) to modify hydrophobicity followed by coupling to various oligoamines (spermine, spermidine, ethylendiamine or… CONTINUE READING
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