Gene transfer efficacies of serum-resistant amino acids-based cationic lipids: dependence on headgroup, lipoplex stability and cellular uptake.

@article{Li2011GeneTE,
  title={Gene transfer efficacies of serum-resistant amino acids-based cationic lipids: dependence on headgroup, lipoplex stability and cellular uptake.},
  author={Li Ken Li and Hongmei Song and Kui Luo and Bin He and Yu Ying Nie and Yang Yang and Yao Qing Wu and Zhongwei Gu},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={408 1-2},
  pages={
          183-90
        }
}
Serum is a major obstacle to efficient cationic liposome-mediated gene transfection. In this paper, three alkaline amino acids based cationic lipids including lysinylated cholesterol (lipid 1), histidinylated cholesterol (lipid 2) and argininylated cholesterol (lipid 3) were used as non-viral gene vectors. The physicochemical properties such as size, Zeta potential, stability and cellular uptake of the lipoplexes formed from lipids 1-3 as well as the transfection efficacies with or without… CONTINUE READING
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