Gene transfer and molecular cloning of the rat nerve growth factor receptor

  title={Gene transfer and molecular cloning of the rat nerve growth factor receptor},
  author={Monte J. Radeke and Thomas P. Misko and Charles Hsu and Leonard A. Herzenberg and Eric M. Shooter},
The amino-acid sequence of one form of the receptor for nerve growth factor defines a new class of growth factor receptors. 
Pleiotropic signaling from receptor tyrosine kinases
Insulin-like growth factor II receptor as a multifunctional binding protein
The primary structure of human insulin-like growth factor II receptor, predicted from the complementary DNA sequence, reveals a transmembrane receptor molecule with a large extracellular domain made
Biochemical characterization of the nerve growth factor receptor in neural-related tumors.
Neurotrophic factors are required for regulation of cell division, cell death, axon outgrowth and synapse formation during fetal development, maintenance of the adult nervous system, and neural
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.
Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar.
1 Nerve Growth Factor and Related Proteins
The juxtaposition of elegant protein biochemistry and insightful tissue culture approaches to the elucidation of the developmental sequelae responsible for selective innervation and neuronal number regulation led to an understanding of cell death processes and neuronal plasticity in response to growth factor cues and later to trauma to the peripheral nervous system and the central nervous system.
Expression Cloning of cDNA Encoding a Putative Opioid Receptor
The first membrane receptor to be cloned was the nicotinic acetylcholine receptor from the specialized electric organs of electric fish — an extraordinarily rich source compared with ordinary skeletal muscle.
A constitutive promoter directs expression of the nerve growth factor receptor gene.
The constitutive nature of the nerve growth factor receptor promoter may account for the ability of this gene to be transcribed in a diverse number of heterologous cells after gene transfer.


Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
The human T-cell growth factor (interleukin-2) receptor is purified and cloned, sequenced and expressed cDNAs corresponding to this receptor and one gene, but two interleukIn-2 receptor mRNAs which differ in their polyadenylation signals are identified.
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the
Molecular cloning of cDNA encoding human interleukin-2 receptor
The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close
Molecular characteristics of nerve growth factor receptors on PC12 cells.
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus
To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, the complete nucleotide sequence of a human c-fms complementary DNA is determined.