Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity.

@article{Hori2002GeneTO,
  title={Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity.},
  author={Rio Hori and Misato Kashiba and Tomoko Toma and Akihiro Yachie and Nobuhito Goda and Nobuya Makino and Akinori Soejima and Toshihiko Nagasawa and Kimimasa Nakabayashi and Makoto Suematsu},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 12},
  pages={
          10712-8
        }
}
Heme oxygenase (HO)-1 is a stress-inducible enzyme protecting cells against oxidative stress, and mechanisms have been considered to depend exclusively on its enzyme activity. This study aimed to examine if the protein lacking catalytic activities could also display such resistance against oxidative stress. Stable transfectants of rat wild type HO-1 cDNA (HO-1-U937) and those of its H25A mutant gene (mHO-1-U937) were established using human monoblastic lymphoma cell U937. HO-1-U937 and mHO-1… CONTINUE READING

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