Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells.

@article{Rischer2006GenetometaboliteNF,
  title={Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells.},
  author={Heiko Rischer and Matej Ore{\vs}i{\vc} and Tuulikki Sepp{\"a}nen-Laakso and Mikko Katajamaa and Freya Lammertyn and Wilson Ardiles-Diaz and Marc C E Van Montagu and Dirk Inz{\'e} and Kirsi-Marja Oksman-Caldentey and Alain Goossens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 14},
  pages={5614-9}
}
Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds. Whereas comprehensive genome-wide functional genomics approaches can be successfully applied to analyze a select number of model plants, these holistic approaches are not yet available for the study of nonmodel plants that include most… CONTINUE READING