Gene therapy vectors based on adeno-associated virus type 1.

  title={Gene therapy vectors based on adeno-associated virus type 1.},
  author={Weidong Xiao and Narendra Chirmule and Scott C. Berta and Beth A. McCullough and Guang-ping Gao and James Michael Wilson},
  journal={Journal of virology},
  volume={73 5},
The complete sequence of adeno-associated virus type 1 (AAV-1) was defined. Its genome of 4,718 nucleotides demonstrates high homology with those of other AAV serotypes, including AAV-6, which appears to have arisen from homologous recombination between AAV-1 and AAV-2. Analysis of sera from nonhuman and human primates for neutralizing antibodies (NAB) against AAV-1 and AAV-2 revealed the following. (i) NAB to AAV-1 are more common than NAB to AAV-2 in nonhuman primates, while the reverse is… CONTINUE READING
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