Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.

@article{Kim2008GeneTU,
  title={Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.},
  author={Seong Muk Kim and Jung Yeon Lim and Sang In Park and Chang Hyun Jeong and Ji Hyeon Oh and Moonsup Jeong and Wonil Oh and Seongjae Park and Young Chul Sung and Sin-Soo Jeun},
  journal={Cancer research},
  year={2008},
  volume={68 23},
  pages={
          9614-23
        }
}
Adenovirus-mediated gene therapies against brain tumors have been limited by the difficulty in tracking glioma cells infiltrating the brain parenchyma. Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSC) are particularly attractive cells for clinical use in cell-based therapies. In the present study, we evaluated the tumor targeting properties and antitumor effects of UCB-MSCs as gene delivery vehicles for glioma therapy. We efficiently engineered UCB-MSCs to deliver a… CONTINUE READING

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