Gene therapy using HVJ-liposomes: the best of both worlds?

  title={Gene therapy using HVJ-liposomes: the best of both worlds?},
  author={Yasufumi Kaneda and Yoshinaga Saeki and Ryuichi Morishita},
  journal={Molecular medicine today},
  volume={5 7},
A new concept for the development of novel vectors is to overcome the limitations of individual vectors by combining them. The HVJ-liposome was developed by combining liposomes with fusion proteins derived from the hemagglutinating virus of Japan (HVJ), also known as Sendai virus. Gene transfer in vivo using this delivery system can be repeated because it is much less immunogenic and cytotoxic than other viral-vector systems. By coupling the Epstein-Barr virus (EBV) replicon apparatus with HVJ… CONTINUE READING

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