Gene therapy to prevent occlusion of venous bypass grafts.

  title={Gene therapy to prevent occlusion of venous bypass grafts.},
  author={Shalini Bhardwaj and Himadri Roy and Seppo Yl{\"a}-Herttuala},
  journal={Expert review of cardiovascular therapy},
  volume={6 5},
Revascularization with vein grafts is standard surgical therapy for occlusive arterial diseases. Autologous saphenous vein grafts are important conduits for repairing blocked coronary arteries and are used in the majority of vein graft procedures. Up to 50% of saphenous vein grafts will be occluded during the first decade after surgery. Vein graft occlusion occurs as a result of neointimal hyperplasia, which takes place in response to hemodynamic changes and vessel wall injury, and is… CONTINUE READING


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