Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.

@article{Trojan1994GeneTO,
  title={Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.},
  author={Jakub S. Trojan and T R Johnson and Susan D. Rudin and B K Blossey and Kevin M. Kelley and Alexei B. Shevelev and Fadi W. Abdul-Karim and Donald D Anthony and Mark L. Tykocinski and Judith Ilan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 13},
  pages={
          6088-92
        }
}
Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. Murine embryonic carcinoma (EC) PCC3 cells express insulin-like growth factor I(IGF-I) and its receptor, while all derivative tumor structures express IGF-I and IGF-II and their… CONTINUE READING

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