Gene therapy of hematopoietic stem cells: strategies for improvement.


Gene therapy of hematopoietic stem cells (HSC) is limited by low frequency of the target cells, their quiescent nature, poor engraftment of treated HSC, and lack of a selective growth advantage of genetically modified cells. Lentiviral vectors combined with positive selection strategies using conditional cell-growth switches should allow for improvement.

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@article{Hossle2002GeneTO, title={Gene therapy of hematopoietic stem cells: strategies for improvement.}, author={Johann Peter Hossle and Reinhard A . Seger and Dirk Steinhoff}, journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society}, year={2002}, volume={17}, pages={87-92} }