Gene therapy of hematopoietic stem cells: strategies for improvement.

Abstract

Gene therapy of hematopoietic stem cells (HSC) is limited by low frequency of the target cells, their quiescent nature, poor engraftment of treated HSC, and lack of a selective growth advantage of genetically modified cells. Lentiviral vectors combined with positive selection strategies using conditional cell-growth switches should allow for improvement.

4 Figures and Tables

Statistics

0100200'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

104 Citations

Semantic Scholar estimates that this publication has 104 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hossle2002GeneTO, title={Gene therapy of hematopoietic stem cells: strategies for improvement.}, author={Johann Peter Hossle and Reinhard A . Seger and Dirk Steinhoff}, journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society}, year={2002}, volume={17}, pages={87-92} }