Gene therapy of experimental brain tumors using neural progenitor cells

@article{Benedetti2000GeneTO,
  title={Gene therapy of experimental brain tumors using neural progenitor cells},
  author={S. De Benedetti and Barbara Pirola and Bianca Pollo and Lorenzo Magrassi and Maria Grazia Bruzzone and Dorotea Rigamonti and R Galli and Silvia Selleri and Francesco Di Meco and Claudio De Fraja and Angelo L. Vescovi and Elena Cattaneo and Gaetano Finocchiaro},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={447-450}
}
Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor prognosis. Gene therapy of glioblastomas is limited by the short survival of viral vectors and by their difficulty in reaching glioblastoma cells infiltrating the brain parenchyma. Neural stem/progenitor cells can be engineered to produce therapeutic molecules and have the potential to overcome these limitations because they may travel along the white matter, like neoplastic cells, and engraft stably into… CONTINUE READING
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