Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.

@article{Luo2004GeneTO,
  title={Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.},
  author={Jian-dong Luo and Ying-Ying Wang and Weiling Fu and Jun Wu and Alex F. Chen},
  journal={Circulation},
  year={2004},
  volume={110 16},
  pages={2484-93}
}
BACKGROUND Nitric oxide (NO) deficiency contributes to diabetic wound healing impairment. The present study tested the hypothesis that increased cutaneous superoxide (O2-) levels in type 1 diabetic mice cause NO deficiency and delayed wound healing. METHODS AND RESULTS Wound healing was markedly delayed in streptozotocin-induced type 1 diabetic mice compared with the normal controls. There were significantly reduced levels of endothelial NO synthase (eNOS) protein and constitutive NOS… CONTINUE READING
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