Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice

@article{Kumar2007GeneTO,
  title={Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice},
  author={M. siddartha Kumar and Yufei Hunag and Yelena Glinka and Gerald Joseph Prud'homme and Q Wang},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={162-172}
}
Glucagon-like peptide (GLP-1), a major physiological incretin, plays numerous important roles in modulating blood glucose homeostasis and has been proposed for the treatment of type 2 diabetes. The major obstacles for using native GLP-1 as a therapeutic agent are that it must be delivered by a parenteral route and has a short half-life. In an attempt to develop a strategy to prolong the physiological t1/2 and enhance the potency of GLP-1, a fusion protein consisting of active human GLP-1 and… CONTINUE READING

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