Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

@article{Ozawa2000GeneTO,
  title={Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.},
  author={Keiya Ozawa and Dong sheng Fan and Yang Shen and Shin-Ichi Muramatsu and Kotarou Fujimoto and Kunihiko Ikeguchi and Masaharu Ogawa and Masashi Urabe and Akihiro Kume and Imaharu Nakano},
  journal={Journal of neural transmission. Supplementum},
  year={2000},
  volume={58},
  pages={181-91}
}
Parkinson's disease (PD) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. A promising approach to the gene therapy of PD is intrastriatal expression of dopamine-synthesizing enzymes [tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC)]. The most appropriate gene-delivery vehicles for neurons are adeno-associated virus (AAV) vectors, which are derived from non-pathogenic virus… CONTINUE READING
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