Gene therapy in the central nervous system: the use of recombinant retroviruses.

@article{Suhr1999GeneTI,
  title={Gene therapy in the central nervous system: the use of recombinant retroviruses.},
  author={Steven Thomas Suhr and Fred H. Gage},
  journal={Archives of neurology},
  year={1999},
  volume={56 3},
  pages={287-92}
}
Only a handful of the hundreds of known vertebrate retroviruses have been deliberately subverted for use as carriers of recombinant genetic material. Retroviruses receive their name from the fact that their genome undergoes conversion from RNA to DNA following infection of a host cell. Also characteristic of retroviruses and uncommon for most other types of viruses is that the genome of the retrovirus integrates itself permanently into the DNA of the host cell. Once integrated into the host… CONTINUE READING

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Retroviridae and their replication

  • JM Coffin
  • 1990
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