Gene therapy in pancreatic cancer.

  title={Gene therapy in pancreatic cancer.},
  author={Si-Xue Liu and Zhong-Sheng Xia and Ying-qiang Zhong},
  journal={World journal of gastroenterology},
  volume={20 37},
Pancreatic cancer (PC) is a highly lethal disease and notoriously difficult to treat. Only a small proportion of PC patients are eligible for surgical resection, whilst conventional chemoradiotherapy only has a modest effect with substantial toxicity. Gene therapy has become a new widely investigated therapeutic approach for PC. This article reviews the basic rationale, gene delivery methods, therapeutic targets and developments of laboratory research and clinical trials in gene therapy of PC… CONTINUE READING
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