Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter.

BACKGROUND Repeated administration of adenoviral vectors can lead to cell resistance, probably because of the initial coxsackie-adenovirus receptor (CAR). Modified adenoviral vectors containing an Arg-Gly-Asp (RGD) sequence can overcome resistance. We constructed an adenoviral vector with RGD-modified fibers, expressing the TRAIL gene from the human… CONTINUE READING