Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect

@article{Goldman1995GeneTI,
  title={Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect},
  author={Mitchell J. Goldman and Yiping Yang and J. M. Wilson},
  journal={Nature Genetics},
  year={1995},
  volume={9},
  pages={126-131}
}
We have developed a model of gene therapy for cystic fibrosis (CF) lung disease, based on growth of human CF bronchial xenografts in nu/nu mice. We now report an evaluation of the primary abnormalities in CF lung epithelia — defective Cl secretion and Na hyperabsorption — in xenografts following adenovirus–mediated gene transfer. In vivo infection of CF xenografts with a cystic fibrosis transmembrane regulator (CFTR) recombinant adenovirus, at a multiplicity of infection equal to 100, was… CONTINUE READING

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